| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Edinson Vólquez | 49.2 | 4 | 2 | 4.35 | 0 | 0 | 47 | 32 | 0.191 |
| Robinson Tejeda | 73.2 | 4 | 2 | 3.54 | 0 | 0 | 87 | 50 | 0.167 |
| Paul Maholm | 194.2 | 8 | 9 | 4.44 | 0 | 0 | 119 | 60 | 0.290 |
| Wandy Rodríguez | 205.2 | 14 | 12 | 3.02 | 0 | 0 | 193 | 63 | 0.250 |
| Hayden Penn | 22.0 | 1 | 0 | 7.77 | 0 | 0 | 27 | 20 | 0.319 |
| Scott Feldman | 189.2 | 17 | 8 | 4.08 | 0 | 0 | 113 | 65 | 0.250 |
| Joe Saunders | 186.0 | 16 | 7 | 4.60 | 0 | 0 | 101 | 64 | 0.279 |
| Scott Olsen | 62.2 | 2 | 4 | 6.03 | 0 | 0 | 42 | 25 | 0.320 |
| Justin Verlander | 240.0 | 19 | 9 | 3.45 | 0 | 0 | 269 | 63 | 0.243 |
| Jason Vargas | 91.2 | 3 | 6 | 4.91 | 0 | 0 | 54 | 24 | 0.281 |
| Fausto Carmona | 125.1 | 5 | 12 | 6.32 | 0 | 0 | 79 | 70 | 0.295 |
| Brian Bannister | 154.0 | 7 | 12 | 4.73 | 0 | 0 | 98 | 50 | 0.268 |
| Chad Billingsley | 196.1 | 12 | 11 | 4.03 | 0 | 0 | 179 | 86 | 0.244 |
| Ryan Rowland-Smith | 96.1 | 5 | 4 | 3.74 | 0 | 0 | 52 | 27 | 0.239 |
| Brandon McCarthy | 97.1 | 7 | 4 | 4.62 | 0 | 0 | 65 | 36 | 0.255 |
| James Shields | 219.2 | 11 | 12 | 4.14 | 0 | 0 | 167 | 52 | 0.275 |
| Jonathan Sánchez | 163.1 | 8 | 12 | 4.24 | 0 | 0 | 177 | 88 | 0.221 |
| Félix Hernández | 238.2 | 19 | 5 | 2.49 | 0 | 0 | 217 | 71 | 0.227 |
| Matt Cain | 217.2 | 14 | 8 | 2.89 | 0 | 0 | 171 | 73 | 0.232 |
| Kyle Davies | 123.0 | 8 | 9 | 5.27 | 0 | 0 | 86 | 66 | 0.265 |
| Chien-Ming Wang | 42.0 | 1 | 6 | 9.64 | 0 | 0 | 29 | 19 | 0.365 |
| Francisco Liriano | 136.2 | 5 | 13 | 5.80 | 0 | 0 | 122 | 65 | 0.279 |
| Cole Hamels | 193.2 | 10 | 11 | 4.32 | 0 | 0 | 168 | 43 | 0.273 |
| Zach Duke | 213.0 | 11 | 16 | 4.06 | 0 | 0 | 106 | 49 | 0.285 |
| Anthony Reyes | 38.1 | 1 | 1 | 6.57 | 0 | 0 | 22 | 23 | 0.274 |
| Ricky Nolasco | 185.0 | 13 | 9 | 5.06 | 0 | 0 | 195 | 44 | 0.259 |
| Sean Marshall | 85.1 | 3 | 7 | 4.32 | 0 | 0 | 68 | 32 | 0.274 |
| Glen Perkins | 96.1 | 6 | 7 | 5.89 | 0 | 0 | 45 | 23 | 0.304 |
| Jason Hammel | 176.2 | 10 | 8 | 4.33 | 0 | 0 | 133 | 42 | 0.290 |
| Jered Weaver | 211.0 | 16 | 8 | 3.75 | 0 | 0 | 174 | 66 | 0.246 |
| Dana Eveland | 44.0 | 2 | 4 | 7.16 | 0 | 0 | 22 | 26 | 0.365 |
| Josh Beckett | 212.1 | 17 | 6 | 3.86 | 0 | 0 | 199 | 55 | 0.244 |
| Shairon Martis | 85.2 | 5 | 3 | 5.25 | 0 | 0 | 34 | 39 | 0.255 |
| Josh Geer | 102.2 | 1 | 7 | 5.96 | 0 | 0 | 54 | 23 | 0.288 |
| Roy Oswalt | 181.1 | 8 | 6 | 4.12 | 0 | 0 | 138 | 42 | 0.265 |
| Justin Miller | 56.2 | 3 | 3 | 3.18 | 0 | 0 | 36 | 27 | 0.236 |
| R.A. Dickey | 64.1 | 1 | 1 | 4.62 | 0 | 0 | 42 | 30 | 0.290 |
| Jonathon Niese | 25.2 | 1 | 1 | 4.21 | 0 | 0 | 18 | 9 | 0.276 |
| Matt Palmer | 121.1 | 11 | 2 | 3.93 | 0 | 0 | 69 | 55 | 0.240 |
| Brad Bergesen | 123.1 | 7 | 5 | 3.43 | 0 | 0 | 65 | 32 | 0.265 |
| Scott Richmond | 138.2 | 8 | 11 | 5.52 | 0 | 0 | 117 | 59 | 0.268 |
| Clayton Richard | 89.0 | 4 | 3 | 4.65 | 0 | 0 | 66 | 37 | 0.276 |
| Kyle Lohse | 117.2 | 6 | 10 | 4.74 | 0 | 0 | 77 | 36 | 0.269 |
| Jeff Samardzija | 34.2 | 1 | 3 | 7.53 | 0 | 0 | 21 | 15 | 0.329 |
| Leo Rosales | 45.1 | 2 | 1 | 4.76 | 0 | 0 | 31 | 12 | 0.237 |
| Eddie Bonine | 34.1 | 1 | 1 | 4.46 | 0 | 0 | 19 | 12 | 0.308 |
| Mitchell Boggs | 58.0 | 2 | 3 | 4.19 | 0 | 0 | 46 | 33 | 0.311 |
| Daniel Ray Herrera | 61.2 | 4 | 4 | 3.06 | 0 | 0 | 44 | 24 | 0.276 |
| Brett Myers | 70.2 | 4 | 3 | 4.84 | 0 | 0 | 50 | 23 | 0.272 |
| Carlos Zambrano | 169.1 | 9 | 7 | 3.77 | 0 | 0 | 152 | 78 | 0.246 |
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