| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| Brian Moehler | 154.2 | 8 | 12 | 5.47 | 0 | 0 | 91 | 51 | 0.298 |
| Liván Hernández | 135.0 | 7 | 8 | 5.47 | 0 | 0 | 75 | 51 | 0.312 |
| Matt Albers | 67.0 | 3 | 6 | 5.51 | 0 | 4 | 49 | 36 | 0.303 |
| Édgar González | 65.1 | 0 | 4 | 5.51 | 0 | 0 | 39 | 28 | 0.292 |
| Scott Richmond | 138.2 | 8 | 11 | 5.52 | 0 | 0 | 117 | 59 | 0.268 |
| Matt Belisle | 31.0 | 3 | 1 | 5.52 | 0 | 0 | 22 | 5 | 0.280 |
| Cory Wade | 27.2 | 2 | 3 | 5.53 | 0 | 6 | 18 | 10 | 0.257 |
| Russ Ortiz | 85.2 | 3 | 6 | 5.57 | 0 | 0 | 65 | 48 | 0.289 |
| Rafael Rodríguez | 30.2 | 0 | 1 | 5.58 | 0 | 2 | 10 | 9 | 0.356 |
| Garrett Olson | 80.1 | 3 | 5 | 5.60 | 0 | 0 | 47 | 34 | 0.258 |
| Brad Penny | 131.2 | 7 | 8 | 5.61 | 0 | 0 | 89 | 42 | 0.299 |
| David Huff | 128.1 | 11 | 8 | 5.61 | 0 | 0 | 65 | 41 | 0.301 |
| Garrett Mock | 91.1 | 3 | 10 | 5.62 | 0 | 2 | 72 | 44 | 0.308 |
| Tom Gorzelanny | 38.1 | 4 | 2 | 5.63 | 0 | 0 | 40 | 13 | 0.262 |
| Armando Galarraga | 143.2 | 6 | 10 | 5.64 | 0 | 0 | 95 | 67 | 0.284 |
| Merkin Valdez | 49.1 | 2 | 1 | 5.66 | 0 | 3 | 38 | 28 | 0.292 |
| Jeff Manship | 31.2 | 1 | 1 | 5.68 | 0 | 0 | 21 | 15 | 0.310 |
| Rodrigo Lopez | 30.0 | 3 | 1 | 5.70 | 0 | 0 | 19 | 11 | 0.339 |
| John Bale | 28.1 | 0 | 1 | 5.72 | 1 | 5 | 24 | 18 | 0.296 |
| Juan Cruz | 50.1 | 3 | 4 | 5.72 | 2 | 6 | 38 | 29 | 0.246 |
| Edwar Ramírez | 22.0 | 0 | 0 | 5.73 | 0 | 0 | 22 | 18 | 0.281 |
| Mike Burns | 51.2 | 3 | 5 | 5.75 | 0 | 0 | 39 | 17 | 0.294 |
| Brent Leach | 20.1 | 2 | 0 | 5.75 | 0 | 0 | 19 | 12 | 0.213 |
| Gio González | 98.2 | 6 | 7 | 5.75 | 0 | 0 | 109 | 56 | 0.288 |
| Daisuke Matsuzaka | 59.1 | 4 | 6 | 5.76 | 0 | 0 | 54 | 30 | 0.325 |
| Bruce Chen | 62.1 | 1 | 6 | 5.78 | 0 | 0 | 45 | 25 | 0.301 |
| Francisco Liriano | 136.2 | 5 | 13 | 5.80 | 0 | 0 | 122 | 65 | 0.279 |
| Matt Capps | 54.1 | 4 | 8 | 5.80 | 27 | 32 | 46 | 17 | 0.324 |
| Paul Byrd | 34.0 | 1 | 3 | 5.82 | 0 | 0 | 11 | 11 | 0.331 |
| Yusmeiro Petit | 89.2 | 3 | 10 | 5.82 | 0 | 0 | 74 | 34 | 0.276 |
| Alan Embree | 24.2 | 2 | 2 | 5.84 | 0 | 3 | 12 | 12 | 0.292 |
| Virgil Vasquez | 44.2 | 2 | 5 | 5.84 | 0 | 0 | 29 | 18 | 0.320 |
| Daniel Cabrera | 40.0 | 0 | 5 | 5.85 | 0 | 0 | 16 | 35 | 0.291 |
| Casey Janssen | 40.0 | 2 | 4 | 5.85 | 1 | 1 | 24 | 14 | 0.341 |
| Shane Loux | 58.1 | 2 | 3 | 5.86 | 0 | 0 | 19 | 19 | 0.343 |
| Manuel Corpas | 33.2 | 1 | 3 | 5.88 | 1 | 3 | 24 | 7 | 0.326 |
| Todd Wellemeyer | 122.1 | 7 | 10 | 5.89 | 0 | 0 | 78 | 57 | 0.328 |
| Matt Lindstrom | 47.1 | 2 | 1 | 5.89 | 15 | 17 | 39 | 24 | 0.281 |
| Glen Perkins | 96.1 | 6 | 7 | 5.89 | 0 | 0 | 45 | 23 | 0.304 |
| Sean O'Sullivan | 51.2 | 4 | 2 | 5.92 | 0 | 0 | 29 | 16 | 0.296 |
| Scott Kazmir | 111.0 | 8 | 7 | 5.92 | 0 | 0 | 91 | 50 | 0.273 |
| José Veras | 25.2 | 3 | 1 | 5.96 | 0 | 0 | 18 | 14 | 0.235 |
| Horacio Ramírez | 22.2 | 0 | 2 | 5.96 | 0 | 1 | 13 | 11 | 0.293 |
| Tomo Ohka | 71.0 | 1 | 5 | 5.96 | 0 | 0 | 31 | 19 | 0.278 |
| Josh Geer | 102.2 | 1 | 7 | 5.96 | 0 | 0 | 54 | 23 | 0.288 |
| Santiago Casilla | 48.1 | 1 | 2 | 5.96 | 0 | 0 | 35 | 25 | 0.303 |
| Jose Arredondo | 45.0 | 2 | 3 | 6.00 | 0 | 1 | 47 | 23 | 0.269 |
| Scott Olsen | 62.2 | 2 | 4 | 6.03 | 0 | 0 | 42 | 25 | 0.320 |
| Carlos Torres | 28.1 | 1 | 2 | 6.04 | 0 | 0 | 22 | 17 | 0.286 |
| Saul Rivera | 38.1 | 1 | 3 | 6.10 | 0 | 1 | 21 | 14 | 0.310 |
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