| MLB Pitching Statistics | |||||||||
| Player | IP | W | L | ERA | SV | SVO | K | BB | BAVG |
| George Sherrill | 27.2 | 1 | 0 | 0.65 | 1 | 3 | 22 | 11 | 0.192 |
| Mike Adams | 37.0 | 0 | 0 | 0.73 | 0 | 1 | 45 | 8 | 0.111 |
| Scott Eyre | 30.0 | 2 | 1 | 1.50 | 0 | 0 | 22 | 16 | 0.206 |
| Joel Hanrahan | 31.1 | 0 | 1 | 1.72 | 0 | 0 | 37 | 20 | 0.204 |
| Jeremy Affeldt | 62.1 | 2 | 2 | 1.73 | 0 | 0 | 55 | 31 | 0.197 |
| Scott Kazmir | 36.1 | 2 | 2 | 1.73 | 0 | 0 | 26 | 10 | 0.212 |
| Neftali Feliz | 31.0 | 1 | 0 | 1.74 | 2 | 3 | 39 | 8 | 0.124 |
| Mariano Rivera | 66.1 | 3 | 3 | 1.76 | 44 | 46 | 72 | 12 | 0.197 |
| Rafael Betancourt | 25.1 | 3 | 1 | 1.78 | 1 | 3 | 29 | 5 | 0.189 |
| Claudio Vargas | 30.1 | 1 | 0 | 1.78 | 0 | 2 | 20 | 11 | 0.175 |
| Brendan Donnelly | 25.1 | 3 | 0 | 1.78 | 2 | 2 | 25 | 9 | 0.239 |
| Trevor Hoffman | 54.0 | 3 | 2 | 1.83 | 37 | 41 | 48 | 14 | 0.183 |
| Andrew Bailey | 83.1 | 6 | 3 | 1.84 | 26 | 30 | 91 | 24 | 0.167 |
| Jonathan Papelbon | 68.0 | 1 | 1 | 1.85 | 38 | 41 | 76 | 24 | 0.213 |
| Ryan Franklin | 61.0 | 4 | 3 | 1.92 | 38 | 43 | 44 | 24 | 0.220 |
| Darren O'Day | 55.2 | 2 | 1 | 1.94 | 2 | 2 | 54 | 17 | 0.188 |
| Kiko Calero | 60.0 | 2 | 2 | 1.95 | 0 | 5 | 69 | 30 | 0.180 |
| Blake Hawksworth | 40.0 | 4 | 0 | 2.03 | 0 | 0 | 20 | 15 | 0.209 |
| Ronald Belisario | 70.2 | 4 | 3 | 2.04 | 0 | 7 | 64 | 29 | 0.201 |
| Trever Miller | 43.2 | 4 | 1 | 2.06 | 0 | 1 | 46 | 11 | 0.197 |
| Joe Nathan | 68.2 | 2 | 2 | 2.10 | 47 | 52 | 89 | 22 | 0.171 |
| LaTroy Hawkins | 63.1 | 1 | 4 | 2.13 | 11 | 15 | 45 | 16 | 0.253 |
| Sammy Gervacio | 21.0 | 1 | 1 | 2.14 | 0 | 1 | 25 | 8 | 0.219 |
| Zack Greinke | 229.1 | 16 | 8 | 2.16 | 0 | 0 | 242 | 51 | 0.230 |
| Francisco Cordero | 66.2 | 2 | 6 | 2.16 | 39 | 43 | 58 | 30 | 0.243 |
| Joakim Soria | 53.0 | 3 | 2 | 2.21 | 30 | 33 | 69 | 16 | 0.219 |
| Chris Carpenter | 192.2 | 17 | 4 | 2.24 | 0 | 0 | 144 | 38 | 0.226 |
| José Valverde | 54.0 | 4 | 2 | 2.33 | 25 | 29 | 56 | 21 | 0.207 |
| José Mijares | 61.2 | 2 | 2 | 2.34 | 0 | 1 | 55 | 23 | 0.224 |
| Matt Guerrier | 76.1 | 5 | 1 | 2.36 | 1 | 4 | 47 | 16 | 0.207 |
| Nick Masset | 76.0 | 5 | 1 | 2.37 | 0 | 2 | 70 | 24 | 0.203 |
| George Sherrill | 41.1 | 0 | 1 | 2.40 | 20 | 23 | 39 | 13 | 0.219 |
| Mike González | 74.1 | 5 | 4 | 2.42 | 10 | 17 | 90 | 33 | 0.209 |
| Takashi Saito | 55.2 | 3 | 3 | 2.43 | 2 | 4 | 52 | 25 | 0.244 |
| Tim Lincecum | 225.1 | 15 | 7 | 2.48 | 0 | 0 | 261 | 68 | 0.206 |
| Félix Hernández | 238.2 | 19 | 5 | 2.49 | 0 | 0 | 217 | 71 | 0.227 |
| Jason Frasor | 57.2 | 7 | 3 | 2.50 | 11 | 14 | 56 | 16 | 0.209 |
| David Aardsma | 71.1 | 3 | 6 | 2.52 | 38 | 42 | 80 | 34 | 0.190 |
| Arthur Rhodes | 53.1 | 1 | 1 | 2.53 | 0 | 2 | 48 | 20 | 0.198 |
| Jeremy Accardo | 24.2 | 0 | 0 | 2.55 | 1 | 1 | 18 | 17 | 0.267 |
| Brian Sanches | 56.1 | 4 | 2 | 2.56 | 0 | 3 | 51 | 26 | 0.235 |
| Brad Penny | 41.2 | 4 | 1 | 2.59 | 0 | 0 | 20 | 9 | 0.205 |
| Kevin Hart | 27.2 | 3 | 1 | 2.60 | 0 | 0 | 13 | 18 | 0.242 |
| Jair Jurrjens | 215.0 | 14 | 10 | 2.60 | 0 | 0 | 152 | 75 | 0.237 |
| Craig Breslow | 55.1 | 7 | 5 | 2.60 | 0 | 2 | 44 | 18 | 0.191 |
| Fu-Te Ni | 31.0 | 0 | 0 | 2.61 | 0 | 2 | 21 | 11 | 0.187 |
| Jonathan Broxton | 76.0 | 7 | 2 | 2.61 | 36 | 42 | 114 | 29 | 0.165 |
| Michael Wuertz | 78.2 | 6 | 1 | 2.63 | 4 | 6 | 102 | 23 | 0.188 |
| Adam Wainwright | 233.0 | 19 | 8 | 2.63 | 0 | 0 | 212 | 66 | 0.244 |
| Jarrod Washburn | 133.0 | 8 | 6 | 2.64 | 0 | 0 | 79 | 33 | 0.223 |
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